Current Issue : January - March Volume : 2016 Issue Number : 1 Articles : 4 Articles
A series of some different azole derivatives such as benzimidazole and 2-amino thiazole were synthesized. All of the synthesized compounds were characterized by TLC, melting point determination, IR, NMR, mass spectral studies and tested for their antifungal activity against the standard strains of candida albicans and asperigilus niger using agar plate diffusion method. The newly synthesized compounds exhibit moderate to excellent growth inhibition of fungi....
A novel series of 5-(1-(Pyridin-3yl-carbonyl)-5-(substituted phenyl)-4,5-dihydro pyrazoline-3-yl)-2-mercaptobenzoxazole (9a-9e) and 5-(1-(Pyridin-3yl-carbonyl)-5-(substituted phenyl)-4,5-dihydro pyrazoline-3-yl)-2-mercaptobenzoxazole (10a-10e) were synthesized, characterized by IR, 1H-NMR, mass analysis and screened for their anti-microbial activity against some gram-positive, gram-negative bacteria and anti-tubercular activity against M. tuberculosis H37RV mycobacterium species with standard drugs. Biological screening results indicated that the synthesized compounds showed a broad spectrum of anti-microbial activity against the tested microorganisms at MIC (μg/ml) values between 100 and 3.25. While the screening results indicated moderate anti-tubercular activity at MIC (μg/ml) values between 25 and 3.25. Activities of series of compounds are found to be impressive for the gram-negative bacterial species....
In the present study N'-benzylidene-4-(2, 5-dimethyl-1H-pyrrol-1-yl) benzohydrazides have been synthesized in good yields and characterized by IR, PMR and mass spectral analysis. Compounds were evaluated for their preliminary in-vitro cytotoxic activity against HeLa cancer cell lines by standard MTT assay and also were screened for antibacterial activity by cup plate method. Our results show that two of the analogues Vc and Vf are potent cytotoxic agents against all the tumor cell lines and antibacterial agents....
In the present study a series of novel purine derivatives were synthesized and evaluated for antimicrobial activity. All the synthesized compounds were characterized by FTIR, 1H NMR and mass spectral. Newly synthesized compounds were screened for their antibacterial (Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa) and antifungal (Aspergillus niger and Candida albicans) activity. The results revealed that, compounds 3a and 3b have exhibited good antifungal activity and compound 3a, 3b and 5 have moderate antibacterial activity against the tested microorganisms....
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